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Pancreatic Islet Transplantation Immunoisolation of Pancreatic Islets (Medical Intelligence Unit) by Robert P. Lanza

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Published by R G Landes Co .
Written in English


  • Surgery,
  • Pancreatic Diseases,
  • Organ Transplantation,
  • Science/Mathematics,
  • Transplantation,
  • Diabetes,
  • Endocrinology,
  • Gastrointestinal & colorectal surgery,
  • Immunology,
  • Transplant surgery,
  • Islands of Langerhans,
  • Islets of Langerhans Transplan,
  • Islets of Langerhans Transplantation

Book details:

Edition Notes

ContributionsWilliam L. Chick (Editor)
The Physical Object
Number of Pages130
ID Numbers
Open LibraryOL8697036M
ISBN 101570591350
ISBN 109781570591358

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Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the . This resource reflects recent advances in the field of pancreas transplantation, especially the increasing number of islet transplantations and the growing interest in stem cell research applicable to this condition. It provides an authoritative account on the current status of the whole organ pancreas transplantation and islet and pancreatic stem cell transplantation. It explores the similarities and differences between human islets and those from other relevant species (rodents, pigs and non-human primates), and how these influence islet isolation. The ultimate goal of this book is to improve the outcome of islet isolation and transplantation in pre .   The long-term success of pancreatic islet transplantation (Tx) as a cure for type 1 diabetes remains limited. Islet loss after Tx related to apoptosis, inflammation and other factors continues to limit its efficacy. In this project we demonstrate a novel approach aimed at protection of islets prior to Tx in non-human primates (NHP, baboons) by silencing a gene (caspase 3) responsible for.

not improve insulin secretion after pancreatic islet transplantation: a phase 3, double-blind, randomized, placebo-controlled trial in type 1 diabetes. Diabetes Care. ; Working Group for Islet Transplantation, The Japanese Pancreas and Islet Transplantation Association. Islet transplantation in Japan – Report from Japanese. Islet-cell transplantation appears to be a fast-growing new subject in the field of experimental research, as a look at the literature shows. There may be two main reasons for this expanding interest: (1) Isolated islets, provided they are clean, undamaged, and numerous, can . Pancreas after kidney transplant (PAK) Pancreas alone transplant (PAT) Patients with type 1 diabetes and advanced kidney disease should be evaluated for both a kidney and pancreas transplant. Islet cell transplantation is a procedure that transplants islets cells from a donor pancreas into the liver of patients with type 1 diabetes. If the. Pre-transplant medical evaluation for pancreas transplant candidates, McCauley & Corry Indications for kidney-pancreas transplantation and patient selection, Haritopoulos & Hakim Indications for solitary pancreas transplantation, Stratta Donor management and selection for pancreatic transplantation, Frezza & Corry

This second edition reflects recent advances in the field, especially the increasing number of islet transplantations and the growing interest in stem cell research applicable to this condition. It. The pancreatic islets or islets of Langerhans are the regions of the pancreas that contain its endocrine (hormone-producing) cells, discovered in by German pathological anatomist Paul Langerhans. The pancreatic islets constitute 1–2% of the pancreas volume and receive 10–15% of its blood flow. The pancreatic islets are arranged in density routes throughout the human pancreas, and are. β-Cell replacement therapy via islet transplantation is a promising possibility for the optimal treatment of type 1 diabetes; however, such an approach is severely limited by the shortage of donor organs. This problem could be overcome if it were possible to generate transplantable islets from stem cells. Although intraportal islet transplantation is still the gold-standard for clinical islet autotransplantation, there are theoretical disadvantages including greater gluco-lipotoxicity and toxin exposure due to the direct contact with portal blood. Intraportal islets may also elicit a rapid endovascular mediated inflammatory reaction [49,